Endocrine Abstracts

Receptor endocytosis plays an important role in regulating the responsiveness of cells to specific hormones. Phosphatidylinositol 4, 5-bisphosphate (PtdIns(4, 5)P2) has been shown to be critical for many endocytic processes including the internalization of G protein-coupled receptors (GPCRs). We have previously shown that depletion of PtdIns(4, 5) P2 by the chemically induced plasma membrane recruitment of a 5-phosphatase domain prevents the internalizati...